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Table 7 Distribution of sMBL levels in RVVI, RVVI types and controls, stratified on the basis of MBL2 additional 5′ variant’s genotypes

From: Impact of SNPs interplay across the locus of MBL2, between MBL and Dectin-1 gene, on women’s risk of developing recurrent vulvovaginal infections

Genotypes

Controls

RVVI

p-value (Controls vs. RVVI)†

BV

p-value (Controls vs. BV)†

VVC

p-value (Controls vs. VVC)†

MI

p-value (Controls vs. MI)†

n

Mean ± SD

n

Mean ± SD

n

Mean ± SD

n

Mean ± SD

n

Mean ± SD

rs11003124

TT

125

1080.5 ± 465.50

155

744.07 ± 495.75

1.8 × 10−8***

64

678.61 ± 390.79a

1.5 × 10−8***

36

442.98 ± 184.28

2.7 × 10−24***

23

634.42 ± 293.56

2.8 × 10−7***

TG

64

1049.9 ± 430.30

90

795.44 ± 531.28

0.002**

27

626.25 ± 326.24b

1.5 × 10−5***

26

458.20 ± 230.82

1.1 × 10−12***

15

887.35 ± 648.44

0.368

GG

14

1313.5 ± 520.39

13

962.81 ± 496.91

0.084

6

1111.8 ± 678.54ab

0.472

0

0.00 ± 0.00

NA

3

850.39 ± 25.19

0.152

p-value

††

0.144

††

0.290

 

††

0.026*

 

†

0.774

 

††

0.234

 

rs7084554

TT

143

1112.4 ± 525.32

147

719.73 ± 478.38

1.4 × 10−10***

59

624.45 ± 325.85

2.0 × 10−13***

35

447.24 ± 207.63

7.3 × 10−23***

21

500.00 ± 104.30f

9.7 × 10−25***

TC

49

1316.7 ± 679.60

95

865.74 ± 602.85

7.7 × 10−5***

28

748.64 ± 483.93

2.1 × 10−4***

27

452.23 ± 201.68

1.4 × 10−11***

17

929.32 ± 665.41f

0.046*

CC

11

1069.6 ± 422.36

16

833.60 ± 321.42

0.111

10

797.20 ± 368.89

0.134

0

0.00 ± 0.00

NA

3

850.39 ± 25.19

0.40

p-value

††

0.080

††

0.097

 

††

0.218

 

†

0.925

 

††

0.01**

 

rs36014597

AA

147

1165.5 ± 577.79

110

720.49 ± 478.04

2.8 × 10−10***

41

634.69 ± 302.67c

1.1 × 10−12***

29

455.00 ± 207.48

1.7 × 10−21***

18

669.20 ± 311.55

2.4 × 10−6***

AG

44

1049.0 ± 440.84

136

796.61 ± 527.34

0.005**

50

680.18 ± 417.03d

7.0 × 10−5***

33

444.32 ± 202.85

2.8 × 10−11***

19

887.19 ± 640.10

0.325

GG

12

1297.6 ± 530.97

12

899.07 ± 428.27

0.325

6

1164.3 ± 670.40cd

0.05*

0

0.00 ± 0.000

NA

4

842.52 ± 430.05

0.145

p-value

††

0.293

††

0.328

 

††

0.01**

 

†

0.839

 

†

0.416

 

rs11003123

GG

84

1086.4 ± 466.75

100

754.57 ± 508.33

8.7 × 10−6***

36

780.92 ± 474.43

0.001***

26

448.89 ± 199.68

1.9 × 10−16***

16

646.30 ± 343.61

0.001***

GA

104

1066.1 ± 430.02

143

769.09 ± 512.02

2.6 × 10−6***

53

598.29 ± 322.96e

3.7 × 10−12***

36

449.89 ± 208.86

1.1 × 10−20***

21

872.59 ± 607.82

0.177

AA

15

1143.8 ± 549.47

15

856.24 ± 384.30

0.108

8

1062.2 ± 604.69e

0.746

0

0.00 ± 0.000

NA

4

896.06 ± 346.68

0.409

p-value

††

0.816

††

0.767

 

††

0.006**

 

†

0.985

 

††

0.365

 
  1. NA not applicable
  2. * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001
  3. †Independent t-test for patient vs. control as well as within groups
  4. ††One Way ANOVA with overall p-value followed by Post Hoc Tukey test that further indicates values with similar letter are significantly different
  5. ap = 0.032, b p = 0.021, c p = 0.007, d p = 0.014, e p = 0.01, f p = 0.013
  6. Genotypes with n < 3 are not included in statistical analysis
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Cell & Bioscience

ISSN: 2045-3701

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