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Table 7 Distribution of sMBL levels in RVVI, RVVI types and controls, stratified on the basis of MBL2 additional 5′ variant’s genotypes

From: Impact of SNPs interplay across the locus of MBL2, between MBL and Dectin-1 gene, on women’s risk of developing recurrent vulvovaginal infections

Genotypes Controls RVVI p-value (Controls vs. RVVI) BV p-value (Controls vs. BV) VVC p-value (Controls vs. VVC) MI p-value (Controls vs. MI)
n Mean ± SD n Mean ± SD n Mean ± SD n Mean ± SD n Mean ± SD
rs11003124
TT 125 1080.5 ± 465.50 155 744.07 ± 495.75 1.8 × 10−8*** 64 678.61 ± 390.79a 1.5 × 10−8*** 36 442.98 ± 184.28 2.7 × 10−24*** 23 634.42 ± 293.56 2.8 × 10−7***
TG 64 1049.9 ± 430.30 90 795.44 ± 531.28 0.002** 27 626.25 ± 326.24b 1.5 × 10−5*** 26 458.20 ± 230.82 1.1 × 10−12*** 15 887.35 ± 648.44 0.368
GG 14 1313.5 ± 520.39 13 962.81 ± 496.91 0.084 6 1111.8 ± 678.54ab 0.472 0 0.00 ± 0.00 NA 3 850.39 ± 25.19 0.152
p-value †† 0.144 †† 0.290   †† 0.026*   0.774   †† 0.234  
rs7084554
TT 143 1112.4 ± 525.32 147 719.73 ± 478.38 1.4 × 10−10*** 59 624.45 ± 325.85 2.0 × 10−13*** 35 447.24 ± 207.63 7.3 × 10−23*** 21 500.00 ± 104.30f 9.7 × 10−25***
TC 49 1316.7 ± 679.60 95 865.74 ± 602.85 7.7 × 10−5*** 28 748.64 ± 483.93 2.1 × 10−4*** 27 452.23 ± 201.68 1.4 × 10−11*** 17 929.32 ± 665.41f 0.046*
CC 11 1069.6 ± 422.36 16 833.60 ± 321.42 0.111 10 797.20 ± 368.89 0.134 0 0.00 ± 0.00 NA 3 850.39 ± 25.19 0.40
p-value †† 0.080 †† 0.097   †† 0.218   0.925   †† 0.01**  
rs36014597
AA 147 1165.5 ± 577.79 110 720.49 ± 478.04 2.8 × 10−10*** 41 634.69 ± 302.67c 1.1 × 10−12*** 29 455.00 ± 207.48 1.7 × 10−21*** 18 669.20 ± 311.55 2.4 × 10−6***
AG 44 1049.0 ± 440.84 136 796.61 ± 527.34 0.005** 50 680.18 ± 417.03d 7.0 × 10−5*** 33 444.32 ± 202.85 2.8 × 10−11*** 19 887.19 ± 640.10 0.325
GG 12 1297.6 ± 530.97 12 899.07 ± 428.27 0.325 6 1164.3 ± 670.40cd 0.05* 0 0.00 ± 0.000 NA 4 842.52 ± 430.05 0.145
p-value †† 0.293 †† 0.328   †† 0.01**   0.839   0.416  
rs11003123
GG 84 1086.4 ± 466.75 100 754.57 ± 508.33 8.7 × 10−6*** 36 780.92 ± 474.43 0.001*** 26 448.89 ± 199.68 1.9 × 10−16*** 16 646.30 ± 343.61 0.001***
GA 104 1066.1 ± 430.02 143 769.09 ± 512.02 2.6 × 10−6*** 53 598.29 ± 322.96e 3.7 × 10−12*** 36 449.89 ± 208.86 1.1 × 10−20*** 21 872.59 ± 607.82 0.177
AA 15 1143.8 ± 549.47 15 856.24 ± 384.30 0.108 8 1062.2 ± 604.69e 0.746 0 0.00 ± 0.000 NA 4 896.06 ± 346.68 0.409
p-value †† 0.816 †† 0.767   †† 0.006**   0.985   †† 0.365  
  1. NA not applicable
  2. * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001
  3. Independent t-test for patient vs. control as well as within groups
  4. ††One Way ANOVA with overall p-value followed by Post Hoc Tukey test that further indicates values with similar letter are significantly different
  5. ap = 0.032, b p = 0.021, c p = 0.007, d p = 0.014, e p = 0.01, f p = 0.013
  6. Genotypes with n < 3 are not included in statistical analysis