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Table 6 MBL2 additional 5′ variant’s distribution and comparison of genotypes and alleles in RVVI types with controls

From: Impact of SNPs interplay across the locus of MBL2, between MBL and Dectin-1 gene, on women’s risk of developing recurrent vulvovaginal infections

  No. (%) of controls No. (%) of VVI types Genotype comparison
BV vs HC VVC vs HC MI vs HC
HC (N = 203) BV (n = 97) VVC (n = 62) MI (n = 41) OR (95% CI) p-value OR (95% CI) p-value OR (95% CI) p-value
rs11003124
 Genotypes
  TT 125 (61.51) 64 (65.91) 36 (58.12) 23 (56.12) 1   1   1  
  TG 64 (31.52) 27 (27.82) 26 (41.91) 15 (36.51) 0.82 (0.47–1.41) 0.48 1.41(0.78–2.53) 0.25 1.27 (0.62–2.60) 0.50
  GG 14 (6.81) 6 (6.11) 0 (0.00) 3 (7.31) 0.83 (0.30–2.28) 0.72 NA 1.16 (0.30–4.37) 0.82
 Alleles
  T 314 (77.31) 155 (79.81) 98 (79.12) 61 (74.31) 1   1   1  
  G 92 (22.62) 39 (20.12) 26 (20.91) 21 (25.62) 0.85 (0.56–1.30) 0.47 0.90 (0.55–1.47) 0.69 1.17 (0.67–2.03) 0.56
rs7084554
 Genotypes
  TT 143 (70.40) 59 (60.82) 35 (56.41) 21 (51.21) 1   1   1  
  TC 49 (24.10) 28 (28.81) 27 (43.52) 17 (41.42) 1.38 (0.79–2.41) 0.24 2.25 (1.23 4.09) 0.007** 2.36 (1.15–4.83) 0.01**
  CC 11 (5.41) 10 (10.30) 0 (0.00) 3 (7.30) 2.20 (0.88–5.46) 0.08 NA 1.85 (0.47–7.20) 0.37
 Alleles
  T 335 (82.50) 146 (75.21) 97 (78.21) 59 (71.90) 1   1   1  
  C 71 (17.40) 48 (24.72) 27 (21.72) 23 (28.01) 1.55 (1.02–2.34) 0.03* 1.31 (0.79–2.15) 0.28 1.83 (1.06–3.17) 0.02*
rs36014597
 Genotypes
  AA 147 (72.40) 41 (42.21) 29 (46.77) 18 (36.51) 1   1   1  
  AG 44 (21.61) 50 (51.51) 33 (53.21) 19 (46.32) 4.07 (2.39–6.94) 3.7 × 10−7*** 3.80(2.08–6.94) 1.7 × 10−5*** 3.52 (1.70–7.29) 0.0007***
  GG 12 (5.91) 6 (6.12) 0 (0.00) 4 (9.70) 1.79 (0.63–5.06) 0.27 NA 2.72 (0.79–9.34) 0.111
 Alleles
  A 338 (83.20) 132 (68.12) 81 (65.31) 49 (59.70) 1   1   1  
  G 68 (16.71) 62 (31.91) 33 (26.62) 27 (32.91) 2.33 (1.56–3.47) 3.6 × 10−5*** 2.02(1.25–3.27) 0.004** 2.73 (1.60–4.68) 0.0002***
rs11003123
 Genotypes
  GG 84 (41.31) 36 (37.11) 26 (41.91) 16 (39.01) 1   1   1  
  GA 104 (51.22) 53 (54.62) 36 (582) 21 (51.21) 1.18 (0.71–1.98) 0.50 1.11 (0.62–1.99) 0.70 1.06 (0.52–2.15) 0.87
  AA 15 (7.38) 8 (8.21) 0 (0.00) 4 (9.71) 1.24 (0.48–3.19) 0.64 NA 1.4 (0.41–4.76) 0.59
 Alleles
  G 272 (66.91) 125 (64.4) 88 (70.91) 53 (64.62) 1   1   1  
  A 134 (33.12) 69 (35.5) 36 (29.12) 29 (35.31) 1.12 (0.78–1.60) 0.53 0.83 (0.53–1.28) 0.40 1.11(0.67–1.82) 0.67
  1. OR odds ratio, CI confidence intervals
  2. * Indicates significant p values (p ≤ 0.05)
  3. ** Indicates high significant values (p ≤ 0.01)
  4. *** Indicates highly significant values (p ≤ 0.001)