Genetic models | Genotype | VVI cases | Controls | OR (95% CI) | p-value | AIC | BIC |
---|---|---|---|---|---|---|---|
(N = 258) | (N = 203) | ||||||
Freq (%) | Freq (%) | ||||||
rs11003124 | |||||||
Codominant | T/T | 155 (60.11) | 125 (61.60) | 1.00 | |||
T/G | 90 (34.92) | 64 (31.50) | 1.14 (0.76–1.69) | 0.53 | 639.4 | 655.9 | |
G/G | 13 (5.00) | 14 (6.90) | 0.75 (0.34–1.65) | 0.58 | |||
Dominant | T/T | 155 (60.10) | 125 (61.60) | 1.00 | |||
T/G-G/G | 103 (39.91) | 78 (38.41) | 1.07 (0.73–1.56) | 0.74 | 638.4 | 650.8 | |
Recessive | T/T-T/G | 245 (95.23) | 189 (93.12) | 1.00 | |||
G/G | 13 (5.00) | 14 (6.90) | 0.72 (0.33–1.56) | 0.4 | 637.8 | 650.2 | |
Overdominant | T/T-G/G | 168 (65.10) | 139 (68.50) | 1.00 | |||
T/G | 90 (34.90) | 64 (31.50) | 1.17 (0.79–1.73) | 0.45 | 637.9 | 650.3 | |
Log-additive | – | – | – | 0.99 (0.73–1.34) | 0.95 | 638.5 | 650.9 |
rs7084554 | |||||||
Codominant | T/T | 147 (56.97) | 143 (70.42) | 1.00 | |||
T/C | 95 (36.82) | 49 (24.11) | 1.90 (1.25–2.89) | 0.002* | 631 | 647.6 | |
C/C | 16 (6.21) | 11 (5.42) | 1.41 (0.63–3.15) | 0.396 | |||
Dominant | T/T | 147 (57.21) | 143 (70.41) | 1.00 | |||
T/C-C/C | 111 (43.12) | 60 (29.60) | 1.81 (1.22–2.68) | 0.002* | 629.5 | 641.9 | |
Recessive | T/T-T/C | 242 (93.80) | 192 (94.60) | 1.00 | |||
C/C | 16 (6.21) | 11 (5.41) | 1.15 (0.52–2.55) | 0.72 | 638.4 | 650.8 | |
Overdominant | T/T-C/C | 163 (63.21) | 154 (75.90) | 1.00 | |||
T/C | 95 (36.81) | 49 (24.12) | 1.85 (1.22–2.79) | 0.003* | 629.7 | 642.1 | |
Log-additive | – | – | – | 1.50 (1.09–2.07) | 0.01* | 632 | 644.4 |
rs36014597 | |||||||
Codominant | A/A | 110 (42.60) | 147 (72.41) | 1.00 | |||
A/G | 136 (52.70) | 44 (21.70) | 4.20 (2.75–6.41) | 1.08 × 10−10** | 592 | 608.5 | |
G/G | 12 (4.70) | 12 (5.90) | 1.33 (0.57–3.08) | 0.497 | |||
Dominant | A/A | 110 (42.60) | 147 (72.41) | 1.00 | |||
A/G-G/G | 148 (57.42) | 56 (27.60) | 3.61 (2.42–5.38) | 8.8 × 10−10** | 596 | 608.4 | |
Recessive | A/A-A/G | 246 (95.31) | 191 (94.12) | 1.00 | |||
G/G | 12(4.70) | 12 (5.90) | 0.77 (0.34–1.77) | 0.54 | 638.1 | 650.5 | |
Overdominant | A/A-G/G | 122 (47.31) | 159 (78.32) | 1.00 | |||
A/G | 136 (52.70) | 44 (21.70) | 4.07 (2.69–6.17) | 1.1 × 10−10** | 590.5 | 602.9 | |
Log-additive | – | – | – | 2.42(1.72–3.41) | 1.2 × 10−6** | 610.8 | 623.2 |
rs11003123 | |||||||
Codominant | G/G | 100 (38.81) | 84 (41.42) | 1.00 | |||
G/A | 143 (55.41) | 104 (51.22) | 1.16(0.79–1.70) | 0.46 | 639.5 | 656 | |
A/A | 15 (5.82) | 15 (7.41) | 0.84 (0.39–1.82) | 0.61 | |||
Dominant | G/G | 100 (38.81) | 84 (41.42) | 1.00 | |||
G/A-A/A | 158 (61.22) | 119 (58.61) | 1.12 (0.77–1.62) | 0.57 | 638.2 | 650.6 | |
Recessive | G/G-G/A | 243 (94.22) | 188 (92.61) | 1.00 | |||
A/A | 15 (5.81) | 15 (7.40) | 0.77 (0.37–1.62) | 0.5 | 638 | 650.4 | |
Overdominant | G/G-A/A | 115 (44.61) | 99 (48.80) | 1.00 | |||
G/A | 143 (55.41) | 104 (51.21) | 1.18 (0.82–1.71) | 0.37 | 637.7 | 650.1 | |
Log-additive | – | – | – | 1.03 (0.76–1.40) | 0.85 | 638.5 | 650.9 |