Fig. 2From: Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosisRegulation of caspase-1 mediated canonical inflammatory pathway. Platform protein, which mainly belong to NLRs, ALRs, and TRIM families. In the inflammasome, the Asp-x cleavage site between the p20 and p10 subunits of caspase-1 was hydrolyzed, followed by the CARD. The cleaved p20 and p10 subunits are polymerized in the form of tetramers to become activated caspase-1Back to article page