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Fig. 2 | Cell & Bioscience

Fig. 2

From: Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis

Fig. 2

Regulation of caspase-1 mediated canonical inflammatory pathway. Platform protein, which mainly belong to NLRs, ALRs, and TRIM families. In the inflammasome, the Asp-x cleavage site between the p20 and p10 subunits of caspase-1 was hydrolyzed, followed by the CARD. The cleaved p20 and p10 subunits are polymerized in the form of tetramers to become activated caspase-1

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