Table 1 MAMs proteins involved in tumorigenesis and tumor progression

AKT

Pancreas (A, D), breast (M), prostate (A)

IP3R, PTEN, PML

Inhibition of calcium release from the ER; antiapoptotic functions

MK-2206

[22, 25, 39,40,41]

BCL-XL

Uterus (A, M), breast (A), prostate (A), colon (A), nervous system (D, M)

BCL-2, IP3R

Induction of calcium leakage from ER; antiapoptotic functions

ABT-737

[30, 42,43,44,45]

BCL-2

B cell (M), central nervous system (A, M), pancreas (D), breast (A)

BCL-XL, IP3R

Induction of calcium leakage from ER; antiapoptotic functions

ABT-737

[31, 43,44,45,46]

MFN-2

Pancreas (A, D), esophagus (M, A, D), prostate (M, A, D)

PERK, MFN-1

Facilitates calcium cross-talk between the ER and mitochondria;Interacts with PERK and regulates PERK-mediated UPR

[47,48,49]

PML

Almost all

AKT, IP3R, PP2A

Regulates apoptosis in the ER by modulating calcium release, negative regulator of Akt

Arsenic trioxide

[24, 27, 50]

PP2A

Prostate (A), central nervous system (M), pancreas (A, D)

AKT, PML

Regulates calcium transients in cardiomyocytes

SMAPs

[51,52,53]

PTEN

Uterus (M), prostate (M, D), head (M, D), stomach (M), breast (A, M), pancreas (M)

AKT, IP3R, PP2A

Negative regulator of Akt, regulation of calcium release via IP3R3; proapoptotic functions

LY-2779964

[54,55,56]

TP53

Almost all

SERCA

Interacts with the C-terminal portion of the SERCA pump, increasing ER Ca2+ loading

Adriamycin

[57,58,59]

PERK

Breast (A)

Involved in folded protein response during ER stress; physically increases contacts between mitochondria and ER

GSK2656157/GSK2606414

[60,61,62]