Fig. 2
The connection between peroxisomes and mitochondria. Mitochondria can communicate with peroxisomes via vesicular transport of MDVs. Key fission components FIS1, MFF, and GDAP1 are shared by both peroxisomes and mitochondria, and they recruit DNM1L to the organelle cleavage site to disrupt organelles. The fatty acid β-oxidation can occur both in mitochondria and peroxisomes. However, the lipid β-oxidation in peroxisomes is not complete, after degrading lipids to medium length, they will be co-transported with acetyl-CoA to the mitochondria for further metabolism. Both mitochondria and peroxisomes can produce ROS, and they are also important organelles for removing ROS and ensuring cell stability. Peroxisomes mainly contain catalase to break down H2O2. ROS are also important signaling molecules, which can induce cell apoptosis