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TableĀ 1 Sixteen downstream genes potentially regulated by TSPY and associated with prognosis in HCC patients

From: The Y-linked proto-oncogene TSPY contributes to poor prognosis of the male hepatocellular carcinoma patients by promoting the pro-oncogenic and suppressing the anti-oncogenic gene expression

Category

Gene symbol (alias)

Function

Effect by TSPY

Effect to HCC survival

DNA replication

CDC45

An initiator for chromosomal DNA replication by recruiting DNA polymerase to chromatin

Upregulated

Unfavorable

PRIM1

A component of the DNA polymerase synthesizing RNA primers for the Okazaki fragments

Upregulated

Unfavorable

RRM2

A ribonucleotide reductase catalyzing the biosynthesis of deoxyribonucleotides from ribonucleotide

Upregulated

Unfavorable

G2/M progression

BUB1

A Ser/Thr protein kinase playing a central role in the spindle checkpoint.

Upregulated

Unfavorable

CDC25B

A Thr protein phosphatase activating CDC2 and CDK1, playing key roles in initiation of G2/M phase

Upregulated

Unfavorable

CENPA

A centromere protein required for the recruitment of kinetochore proteins to centromere

Upregulated

Unfavorable

PRC1

A key regulator of cytokinesis by forming spatiotemporal midzone with KIF14, central spindle and midbody

Upregulated

Unfavorable

SPC24

A component of NDC80 complex organizing the stable microtubule binding sites of the kinetochore

Upregulated

Unfavorable

Membrane receptors

ADGRD1 (GPR133)

A G-protein-coupled membrane receptor

Upregulated

Unfavorable

HMMR (RHAMM)

A receptor of hyaluronic acid (HA); intracellular HMMR plays a role in cytokinesis

Upregulated

Unfavorable

DNA repair and recombination

EXO1

A DNA exonuclease functioning in DNA mismatch repair

Upregulated

Unfavorable

RAD51

A component of the DNA repairing machinery in homologous recombination

Upregulated

Unfavorable

Others

EGLN3 (PDH3)

A prolyl hydroxylase regulating the activities of HIFs

Upregulated

Unfavorablea

PPARGC1A (PGC-1a)

A transcriptional coactivator of PPARgammma

Downregulated

Favorable

SLC25A25

A calcium-dependent mitochondrial solute carrier

Downregulated

Favorable

SOCS2 (MCSC)

A negative regulator of cytokine receptor signaling

Downregulated

Favorable

  1. Full table is presented as Additional file 7: Table S4
  2. aThe role of EGLN3 in HCC seems to be controversial