Table 1 Sixteen downstream genes potentially regulated by TSPY and associated with prognosis in HCC patients
Category | Gene symbol (alias) | Function | Effect by TSPY | Effect to HCC survival |
|---|---|---|---|---|
DNA replication | CDC45 | An initiator for chromosomal DNA replication by recruiting DNA polymerase to chromatin | Upregulated | Unfavorable |
PRIM1 | A component of the DNA polymerase synthesizing RNA primers for the Okazaki fragments | Upregulated | Unfavorable | |
RRM2 | A ribonucleotide reductase catalyzing the biosynthesis of deoxyribonucleotides from ribonucleotide | Upregulated | Unfavorable | |
G2/M progression | BUB1 | A Ser/Thr protein kinase playing a central role in the spindle checkpoint. | Upregulated | Unfavorable |
CDC25B | A Thr protein phosphatase activating CDC2 and CDK1, playing key roles in initiation of G2/M phase | Upregulated | Unfavorable | |
CENPA | A centromere protein required for the recruitment of kinetochore proteins to centromere | Upregulated | Unfavorable | |
PRC1 | A key regulator of cytokinesis by forming spatiotemporal midzone with KIF14, central spindle and midbody | Upregulated | Unfavorable | |
SPC24 | A component of NDC80 complex organizing the stable microtubule binding sites of the kinetochore | Upregulated | Unfavorable | |
Membrane receptors | ADGRD1 (GPR133) | A G-protein-coupled membrane receptor | Upregulated | Unfavorable |
HMMR (RHAMM) | A receptor of hyaluronic acid (HA); intracellular HMMR plays a role in cytokinesis | Upregulated | Unfavorable | |
DNA repair and recombination | EXO1 | A DNA exonuclease functioning in DNA mismatch repair | Upregulated | Unfavorable |
RAD51 | A component of the DNA repairing machinery in homologous recombination | Upregulated | Unfavorable | |
Others | EGLN3 (PDH3) | A prolyl hydroxylase regulating the activities of HIFs | Upregulated | Unfavorablea |
PPARGC1A (PGC-1a) | A transcriptional coactivator of PPARgammma | Downregulated | Favorable | |
SLC25A25 | A calcium-dependent mitochondrial solute carrier | Downregulated | Favorable | |
SOCS2 (MCSC) | A negative regulator of cytokine receptor signaling | Downregulated | Favorable |