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TableĀ 1 Sixteen downstream genes potentially regulated by TSPY and associated with prognosis in HCC patients

From: The Y-linked proto-oncogene TSPY contributes to poor prognosis of the male hepatocellular carcinoma patients by promoting the pro-oncogenic and suppressing the anti-oncogenic gene expression

Category Gene symbol (alias) Function Effect by TSPY Effect to HCC survival
DNA replication CDC45 An initiator for chromosomal DNA replication by recruiting DNA polymerase to chromatin Upregulated Unfavorable
PRIM1 A component of the DNA polymerase synthesizing RNA primers for the Okazaki fragments Upregulated Unfavorable
RRM2 A ribonucleotide reductase catalyzing the biosynthesis of deoxyribonucleotides from ribonucleotide Upregulated Unfavorable
G2/M progression BUB1 A Ser/Thr protein kinase playing a central role in the spindle checkpoint. Upregulated Unfavorable
CDC25B A Thr protein phosphatase activating CDC2 and CDK1, playing key roles in initiation of G2/M phase Upregulated Unfavorable
CENPA A centromere protein required for the recruitment of kinetochore proteins to centromere Upregulated Unfavorable
PRC1 A key regulator of cytokinesis by forming spatiotemporal midzone with KIF14, central spindle and midbody Upregulated Unfavorable
SPC24 A component of NDC80 complex organizing the stable microtubule binding sites of the kinetochore Upregulated Unfavorable
Membrane receptors ADGRD1 (GPR133) A G-protein-coupled membrane receptor Upregulated Unfavorable
HMMR (RHAMM) A receptor of hyaluronic acid (HA); intracellular HMMR plays a role in cytokinesis Upregulated Unfavorable
DNA repair and recombination EXO1 A DNA exonuclease functioning in DNA mismatch repair Upregulated Unfavorable
RAD51 A component of the DNA repairing machinery in homologous recombination Upregulated Unfavorable
Others EGLN3 (PDH3) A prolyl hydroxylase regulating the activities of HIFs Upregulated Unfavorablea
PPARGC1A (PGC-1a) A transcriptional coactivator of PPARgammma Downregulated Favorable
SLC25A25 A calcium-dependent mitochondrial solute carrier Downregulated Favorable
SOCS2 (MCSC) A negative regulator of cytokine receptor signaling Downregulated Favorable
  1. Full table is presented as Additional file 7: Table S4
  2. aThe role of EGLN3 in HCC seems to be controversial