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Fig. 5 | Cell & Bioscience

Fig. 5

From: The Y-linked proto-oncogene TSPY contributes to poor prognosis of the male hepatocellular carcinoma patients by promoting the pro-oncogenic and suppressing the anti-oncogenic gene expression

Fig. 5

Schematic diagram illustrating the functions of TSPY and TSPY-downstream genes in cell cycle events, particularly mitosis, in HCC. From top-left; CDC45, RRM2 and PRIM1 participate in DNA replication at S-phase; CDC25B activates cyclin-B/CDK1 complex and promotes M-phase entry. TSPY binds cyclin-B/CDK1 complex and enhances its activity. BUB1, CENPA, and SPC24 interact with the condensed chromatin and participate in spindle assembly checkpoint and chromatin segregation respectively. HMMR promotes spindle pole formation; PRC1 binds microtubules and modulates cytokinesis. HMMR also activates the signaling cascades of cell-proliferation via extracellular hyaluronan

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