Gene | Relative to Sham |
---|
Sham | Wound | RI | CI |
---|
p21 | 1.0 | 0.4a | 19.7b | 35.9c |
Bax | 1.0 | 0.5a | 8.6b | 17.5c |
Bcl-2 | 1.0 | 1.4 | 1.6 | 2.0 |
Bax/Bcl-2 | 1.0 | 0.4a | 5.5b | 8.6c |
DDB2 | 1.0 | 1.1 | 5.7b | 7.9c |
Gadd45α | 1.0 | 1.1 | 5.2b | 4.6b |
TERT | 1.0 | 0.1a | 0.7b | 0.3c |
- B6F2D1/J female mice received 8.5 Gy 60Co gamma (RI) or 8.5 Gy followed by 15% total body surface area skin wound trauma 1 h after radiation (CI). The skin wound was to remove panniculus carnosus muscle and overlying skin (23.5 ± 1.1 mm in length and 14.9 ± 0.7 mm in width; see ref. [15]). Gene expression in bone marrow 24 h after RI or CI was measured using real-time PCR. Each group contained 6 mice
- DDB2 DNA damage-binding protein 2, Gadd45α Growth arrest and DNA-inducible protein 45α, TERT telomerase reverse transcriptase
- aP < 0.05 vs. Sham, RI, and CI
- bP < 0.05 vs. Sham, Wound, and CI
- cP < 0.05 vs. Sham, Wound, and RI; determined by Chi square test