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Table 3 Gene expression in bone marrow after radiation injury and radiation combined injury [78 ]

From: Radiation: a poly-traumatic hit leading to multi-organ injury

Gene Relative to Sham
Sham Wound RI CI
p21 1.0 0.4a 19.7b 35.9c
Bax 1.0 0.5a 8.6b 17.5c
Bcl-2 1.0 1.4 1.6 2.0
Bax/Bcl-2 1.0 0.4a 5.5b 8.6c
DDB2 1.0 1.1 5.7b 7.9c
Gadd45α 1.0 1.1 5.2b 4.6b
TERT 1.0 0.1a 0.7b 0.3c
  1. B6F2D1/J female mice received 8.5 Gy 60Co gamma (RI) or 8.5 Gy followed by 15% total body surface area skin wound trauma 1 h after radiation (CI). The skin wound was to remove panniculus carnosus muscle and overlying skin (23.5 ± 1.1 mm in length and 14.9 ± 0.7 mm in width; see ref. [15]). Gene expression in bone marrow 24 h after RI or CI was measured using real-time PCR. Each group contained 6 mice
  2. DDB2 DNA damage-binding protein 2, Gadd45α Growth arrest and DNA-inducible protein 45α, TERT telomerase reverse transcriptase
  3. aP < 0.05 vs. Sham, RI, and CI
  4. bP < 0.05 vs. Sham, Wound, and CI
  5. cP < 0.05 vs. Sham, Wound, and RI; determined by Chi square test