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Table 3 Gene expression in bone marrow after radiation injury and radiation combined injury [78 ]

From: Radiation: a poly-traumatic hit leading to multi-organ injury

Gene

Relative to Sham

Sham

Wound

RI

CI

p21

1.0

0.4a

19.7b

35.9c

Bax

1.0

0.5a

8.6b

17.5c

Bcl-2

1.0

1.4

1.6

2.0

Bax/Bcl-2

1.0

0.4a

5.5b

8.6c

DDB2

1.0

1.1

5.7b

7.9c

Gadd45α

1.0

1.1

5.2b

4.6b

TERT

1.0

0.1a

0.7b

0.3c

  1. B6F2D1/J female mice received 8.5 Gy 60Co gamma (RI) or 8.5 Gy followed by 15% total body surface area skin wound trauma 1 h after radiation (CI). The skin wound was to remove panniculus carnosus muscle and overlying skin (23.5 ± 1.1 mm in length and 14.9 ± 0.7 mm in width; see ref. [15]). Gene expression in bone marrow 24 h after RI or CI was measured using real-time PCR. Each group contained 6 mice
  2. DDB2 DNA damage-binding protein 2, Gadd45α Growth arrest and DNA-inducible protein 45α, TERT telomerase reverse transcriptase
  3. aP < 0.05 vs. Sham, RI, and CI
  4. bP < 0.05 vs. Sham, Wound, and CI
  5. cP < 0.05 vs. Sham, Wound, and RI; determined by Chi square test