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Fig. 8 | Cell & Bioscience

Fig. 8

From: MFAP5 promotes basal-like breast cancer progression by activating the EMT program

Fig. 8

TGF-β and Notch pathways mediated the promoting effects of MPAP5 on BLBC cells motility. a BT20-LV-vehicle and BT20-LV-MFAP5 cells were treated with SB431542 or ly-411575 as indicated for 0, 24, 48 and 72 h. Then the OD value of cells was measured. Overexpression of MFAP5 time dependently improved the OD value compared to LV-vehicle group. But OD value elevated by MFAP5 was strikingly weakened by SB431542 and ly-411575. **P < 0.01 vs LV-vehicle control; ##P < 0.01 vs LV-MFAP5 control. b The OD value of cells at 72 h was presented. MFAP5 significantly increased cell OD value which was attenuated by SB431542 and ly-411575. **P < 0.01 vs LV-vehicle control; ##P < 0.01 vs LV-MFAP5 control. c BT20-LV-vehicle and BT20-LV-MFAP5 cells were treated with SB431542 or ly-411575 as indicated for 24 h, and the invasion was measured by transwell migration assay. Compared with LV-vehicle group, the number of BT20 cell invasion was significantly increased in LV-MFAP5 group which were remarkably abolished by SB431542 and ly-411575. **P < 0.01 vs LV-vehicle control; ##P < 0.01 vs LV-MFAP5 control

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