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Fig. 7 | Cell & Bioscience

Fig. 7

From: XPD suppresses cell proliferation and migration via miR-29a-3p-Mdm2/PDGF-B axis in HCC

Fig. 7

XPD suppressed proliferation and migration of HCC cell via miR-29a-3p-Mdm2/PDGF-B axis. a Western blotting analysis of Mdm2, P53 and PDGF-B expression in SMMC7721 cells after transfection with XPD overexpression plasmid and miR-29a-3p inhibitor. (*P < 0.05, vs. vector + inhibitor NC; #P < 0.05, vs. vector + miR-29a-3p inhibitor). b Western blotting analysis of Mdm2, P53 and PDGF-B expression in Hep3B cells after transfection with XPD siRNA and miR-29a-3p mimic. (*P < 0.05, vs. scramble + mimic NC; #P < 0.05, vs. scramble + miR-29a-3p mimic). c Proliferation ability test by MTT assay of SMMC7721 cells after transfection with XPD overexpression, Mdm2 overexpression plasmid or PDGF-B overexpression plasmid. ($P < 0.05, vs. vector; &P < 0.05, vs. XPD). d Transwell migration assay of SMMC7721 cells after transfection with XPD overexpression, Mdm2 overexpression plasmid or PDGF-B overexpression plasmid. ($P < 0.05, vs. vector; &P < 0.05, vs. XPD)

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