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Fig. 9 | Cell & Bioscience

Fig. 9

From: Exosomes from hyperglycemia-stimulated vascular endothelial cells contain versican that regulate calcification/senescence in vascular smooth muscle cells

Fig. 9

The role of VCAN in HG-HUVEC-Exos-induced VSMCs senescence/calcification. HUVECs were transfected with negative control siRNA (con-siRNA) or VCAN siRNA (VCAN-siRNA) for 6 h and then exposed to HG condition for 48 h. After that, exosomes were isolated and co-cultured with VSMC for 48 h. VSMCs were co-cultured with HUVEC-Exos for 10 days/48 h, calcification/senescence were measured by Alizarin Red Staining/SA-β-gal staining, respectively (400×)

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