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Fig. 8 | Cell & Bioscience

Fig. 8

From: Exosomes from hyperglycemia-stimulated vascular endothelial cells contain versican that regulate calcification/senescence in vascular smooth muscle cells

Fig. 8

The role of VCAN in HG-HUVEC-Exos-induced VSMCs senescence/calcification. HUVECs were transfected with negative control siRNA (con-siRNA) or VCAN siRNA (VCAN-siRNA) for 6 h and then exposed to HG condition for 48 h. After that, exosomes were isolated and co-cultured with VSMC for 48 h. a VCAN mRNA and protein expression were assessed by qRT-PCR and Western blot. b MDA content, LDH and SOD activity were determined by using commercial kits. Data are presented as the means ± SEM of three independent experiments. Statistical analysis was performed by using one-way ANOVA test. **p < 0.01 compared with con-siRNA group

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