Fig. 6

TUG1 knockdown sensitized ESCC cells to DDP in vivo. ECA109/DDP cells stably transfected with sh-con or sh-TUG1 were subcutaneously inoculated into the nude mice, followed by treatment with PBS or DDP. Mice were killed and removed tumors at 42 days after inoculation. a The tumor volumes were measured every week. b The typical photographs and average weights of resected tumors. c qRT-PCR analysis of TUG1 and PDCD4 mRNA levels in excised tumor tissues. d Western blot analysis PDCD4 protein level in excised tumor tissues. *P < 0.05