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Fig. 2 | Cell & Bioscience

Fig. 2

From: The roles of lncRNA in hepatic fibrosis

Fig. 2

lncRNAs regulate hepatic fibrosis via TGF-β signaling pathway. a MALAT1 represses SIRT1 to inhibit the deacetylation of Smad3. Then the deacetylation of Smad3 binds to fibrogenic genes, such as colIα1, to induce the expression of colIα1. b lnc-LFAR1 is induced by Smad2/3 and in turn to promote the phosphorylation of Smad2/3, that provides a positive feedback loop to enhance Smad2/3 binding to the target gene, therefore causing the high expression of colIα1 and α-SMA. The deposition of ECM and activation of HSCs contribute to the hepatic fibrosis

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