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Fig. 4 | Cell & Bioscience

Fig. 4

From: Circ_0027599/PHDLA1 suppresses gastric cancer progression by sponging miR-101-3p.1

Fig. 4

Circ_0027599 suppressed gastric cancer cell proliferation. a Circ_0027599 expression in MKN-28 and HGC-27 cells. MKN-28 and HGC-27 cells were transfected with circ_0027599 and circ_0027599 levels were analyzed by qRT-PCR. b PHLDA1 levels in MKN-28 and HGC-27 cells. MKN-28 and HGC-27 cells were transfected with circ_0027599 and PHLDA1 levels were analyzed by western blotting. c miR-101 levels in MKN-28 and HGC-27 cells. MKN-28 and HGC-27 cells were transfected with circ_0027599 and miR-101 levels were analyzed by western qRT-PCR. d, e Circ_0027599 reduced gastric cancer cell proliferation. MKN-28 and HGC-27 cells were transfected with circ_0027599, miR-101, or PHLDA1 siRNA and survival ability was analyzed by CCK8 assay at the day 1 and day 3. f, g Circ_0027599 reduced gastric cancer cell invasion. MKN-28 and HGC-27 cells were transfected with circ_0027599, miR-101, or PHLDA1 siRNA and invasion ability was analyzed by transwell chambers with matrigel treatment. **p < 0.01; *p < 0.05

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