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Fig. 4 | Cell & Bioscience

Fig. 4

From: TIPE2 acts as a biomarker for tumor aggressiveness and suppresses cell invasiveness in papillary thyroid cancer (PTC)

Fig. 4

TIPE2 suppressed the invasiveness of PTC cells via inhibiting Rac1. a IHC results (×200 magnification) of Rac1 expression in PTC tissues with or without infiltration. b IHC sum scores were used to compare TIPE2 expression in PTC tissues with or without infiltration. c The invasiveness of TPC-1 and B-CPAP cells were measured by Transwell invasion assays after transfection of specific Rac1 siRNA. d After treatment of NSC23766, Transwell invasion assays were used to evaluate the invasiveness of TPC-1 and B-CPAP cells. e TPC-1 and B-CPAP cells co-transfected with Rac1-specific siRNA and TIPE2 overexpressing plasmid were used for Transwell invasion assays. f TPC-1 and B-CPAP cells that transfected with Mock, wild type TIPE2 and mutant TIPE2 plasmids were used for Transwell invasion assays. Data are shown as the mean ± SD, and the results shown are representative of 3 independent experiments. Five fields of cells in the lower compartment were counted in Transwell assays (200 × magnification). **P < 0.01

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