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Fig. 2 | Cell & Bioscience

Fig. 2

From: Role of MCM2–7 protein phosphorylation in human cancer cells

Fig. 2

Roles of MCM phosphorylation mediated by p56Lyn, Akt and ILK in cancer development. Phosphorylation of MCM7 mediated by EGFR-p56Lyn and RACK1-Akt promotes MCM complex assembly and chromatin loading, therefore enhancing DNA synthesis and cancer cell proliferation. In contrast, MCM7 phosphorylation mediated by ITGA7-ILK axis reduces MCM7 chromatin association, inhibiting cell growth

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