Fig. 2
From: Role of MCM2–7 protein phosphorylation in human cancer cells
Roles of MCM phosphorylation mediated by p56Lyn, Akt and ILK in cancer development. Phosphorylation of MCM7 mediated by EGFR-p56Lyn and RACK1-Akt promotes MCM complex assembly and chromatin loading, therefore enhancing DNA synthesis and cancer cell proliferation. In contrast, MCM7 phosphorylation mediated by ITGA7-ILK axis reduces MCM7 chromatin association, inhibiting cell growth