Skip to main content

Advertisement

Fig. 1 | Cell & Bioscience

Fig. 1

From: Role of MCM2–7 protein phosphorylation in human cancer cells

Fig. 1

Schematic diagram summarizing the roles of MCM phosphorylation mediated by three classes of kinases Cdc7, Cdk and ATM/ATR. Although many functional crosstalks exist between MCM kinases-mediated phosphorylation events, evidence shows that Cdc7-dependent MCM phosphorylation primarily promotes the initiation of DNA replication, Cdk-dependent MCM phosphorylation mainly contributes to cell cycle progression regulation, and ATM/ATR-dependent MCM phosphorylation primarily responds to replication stress. MCM phosphorylation contributes to these various functions primarily by affecting MCM complex formation, chromatin binding, and (or) helicase activity

Back to article page