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Fig. 1 | Cell & Bioscience

Fig. 1

From: Role of MCM2–7 protein phosphorylation in human cancer cells

Fig. 1

Schematic diagram summarizing the roles of MCM phosphorylation mediated by three classes of kinases Cdc7, Cdk and ATM/ATR. Although many functional crosstalks exist between MCM kinases-mediated phosphorylation events, evidence shows that Cdc7-dependent MCM phosphorylation primarily promotes the initiation of DNA replication, Cdk-dependent MCM phosphorylation mainly contributes to cell cycle progression regulation, and ATM/ATR-dependent MCM phosphorylation primarily responds to replication stress. MCM phosphorylation contributes to these various functions primarily by affecting MCM complex formation, chromatin binding, and (or) helicase activity

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