Fig. 7
From: Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease
mHTT increases the mRNA levels of Tf, TfR and ferritin. a1–c1 Tf, TfR, and ferritin mRNA levels were detected by RT-PCR both in TG mice brain (a1 cortex; b1 striatum) and in 160Q HEK293 cells at 72 h after transfection (c1). a2–c2 Quantitative representation of Tf, TfR, and ferritin band intensity normalized to β-actin. Tf, TfR, and ferritin mRNA levels are increased both in the cortex and striatum of TG mice and in 160Q HEK293 cells compared to controls. n = 4. *p < 0.05 compared to WT mice, or 20Q HEK293 cells