Fig. 6
From: Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease
mHTT increases the protein levels of Tf, TfR and ferritin. a1–c1 Tf, TfR, and ferritin protein expressions were detected by Western blotting both in TG mice brain (a1 cortex; b1 striatum) and in 160Q HEK293 cells at 48 h or 72 h after transfection (c1). a2–c2 Quantitative representation of Tf, TfR, and ferritin band intensity normalized to GAPDH. Tf, TfR, and ferritin protein levels are increased both in the cortex and striatum of TG mice and in 160Q HEK293 cells compared to controls. n = 4. *p < 0.05 compared to WT mice, or 20Q HEK293 cells