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Fig. 6 | Cell & Bioscience

Fig. 6

From: Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease

Fig. 6

mHTT increases the protein levels of Tf, TfR and ferritin. a1c1 Tf, TfR, and ferritin protein expressions were detected by Western blotting both in TG mice brain (a1 cortex; b1 striatum) and in 160Q HEK293 cells at 48 h or 72 h after transfection (c1). a2c2 Quantitative representation of Tf, TfR, and ferritin band intensity normalized to GAPDH. Tf, TfR, and ferritin protein levels are increased both in the cortex and striatum of TG mice and in 160Q HEK293 cells compared to controls. n = 4. *p < 0.05 compared to WT mice, or 20Q HEK293 cells

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