Fig. 5

The striatum and cortex of N171-82Q mice display dense TfR and ferritin immunoreactivities. a–d The expression of TfR (a and b) and ferritin (c, d) was detected by immunohistochemistry in striatum and cortex of 12-week-old TG mice and age-matched WT mice. a2–d2, respectively are the amplified images of squared areas in a1–d1. a4–d4, respectively are the amplified images of squared areas in a3–d3. Arrowheads show positive TfR, and ferritin. Bar in a1, a3, b1, b3, c1, c3, d1 and d3 is 100 μm, and bar in a2, a4, b2, b4, c2, c4, d2 and d4 is 25 μm. e1, e2 Integrated optical density measurement shows that both TfR and ferritin immunoreactivities are increased in the TG mice compared to WT mice. n = 3. *p < 0.05 compared to WT mice