Fig. 2
From: Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease
The N171-82Q mice displays dense IRP1-immunoreactivities in striatum and cortex. a–d IRP1 expression was detected in cortex and striatum of 12-week-old TG mice and age-matched WT mice by immunohistochemistry. a2–d2, respectively are the amplified images of squared areas in a1–d1. Arrowheads show positive IRP1 staining. Bar in a1–d1 is 100 μm, and bar in a2–d2 is 25 μm. e Integrated optical density measurement shows the difference in IRP1 immunoreactivity whose expression is significantly increased in cortex and striatum of TG mice. n = 3. *p < 0.05 compared to WT mice