Fig. 1
From: Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease
Irons levels increase in striatum and cortex of N171-82Q mice. a–d Irons levels were detected in striatum and cortex of 12-week-old N171-82Q HD transgenic (TG) mice and age-matched wild type (WT) mice by DAB-enhanced Perls’ stain. a2–d2 respectively are the amplified images of squared areas in a1–d1. Arrowheads show iron deposition. Bar in a1–d1 is 100 μm, and bar in a2–d2 is 25 μm. e Integrated optical density measurement shows the difference in iron staining. Compared to age-matched WT mice, the iron levels increase in striatum and cortex of TG mice. n = 3. *p < 0.05 compared to WT mice