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Fig. 2 | Cell & Bioscience

Fig. 2

From: RINCK-mediated monoubiquitination of cGAS promotes antiviral innate immune responses

Fig. 2

RINCK deficiency attenuates cytosolic DNA-triggered cGAS/STING signaling. a, b WT or RINCK-deficient U937 cells were treated with HT-DNA or ISD for indicated time followed by immunoblotting with indicated antibodies. c HeLa cells were transfected with the negative control (NC) or RINCK siRNAs for 48 h followed by measuring RINCK mRNA with qPCR. d HeLa cells were transfected with the negative control (NC) or RINCK siRNA for 48 h and then were treated with HT-DNA for 3 h followed by immunoblotting with indicated antibodies. Data are presented as the mean ± SD. ***P < 0.001. Data represent three independent experiments

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