Fig. 1
From: RINCK-mediated monoubiquitination of cGAS promotes antiviral innate immune responses
RINCK is required for cytosolic DNA-induced type I interferon production. a Schematic drawing of the RINCK deletion in U937 cells. b, c WT or RINCK-deficient U937 cells were treated with HT-DNA or ISD for indicated time followed by measuring interferon (IFN)-β mRNA with qPCR. d, e WT or RINCK-deficient U937 cells were treated with HT-DNA or ISD for 12 h, and the culture medium was collected for quantification of IFN-β by ELISA. f, g U937 cells were treated with HT-DNA or IFN-β for indicated time followed by measuring mRNA levels of RINCK and Rsad2 with qPCR. Data are presented as the mean ± SD. **P < 0.01, ***P < 0.001. N.D., not detected. Data represent three independent experiments