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Table 1 Calcium related gene expression and macrophage functions

From: Syncytium calcium signaling and macrophage function in the heart

# Gene name Functions of enconded gene PubMed ID Chromosome location Transcript (bp) CDS (bp) References
1 MIP-1α Activating inflammatory response NM_002983.2 Chr 17:36088256-36090160 813 279 Provost et al. [34]
2 MIP-1β Activating inflammatory response NM_002984.3 Chr 17:36103827-36105621 667 279 Provost et al. [34]
3 Toll-like receptor 4 (TLR4) Activation of TRPC6-dependent calcium signaling mediates endotoxin induced lung vascular permeability and inflammation NM_021297.3 Chr 9:117704175-117717491 5494 1920 Tauseef et al. [35]
4 STIM1 Mediate extracellular Ca2+ entry NM_001277961.1 Chr 11:3855703-4093210 4380 2376 Steinckwich et al. [36]
5 Orai1 Mediate extracellular Ca2+ entry NM_032790.3 Chr 12:121626550-121642040 1496 906 Steinckwich et al. [36]
6 S100A8 As the site of interplay between extracellular Ca2+ entry and intraphagosomal ROS production NM_001319197.1 Chr 1:1533590032-153422583 546 351 Steinckwich et al. [36]
7 S100A9 As the site of interplay between extracellular Ca2+ entry and intraphagosomal ROS production NM_002965.3 Chr 1:153357854-153361027 586 345 Steinckwich et al. [36]
8 Transient receptor potential vanilloid 2 (TRPV2) Participation early phagocytosis and innate immunity NM_016113.4 Chr 17:16415542-16437003 2829 2295 Link et al. [29]
9 lL-10 Activating immunoreaction NM_000572.2 Chr 1:206767603-206772494 1629 537 Kelly et al. [37]
C-type lectin receptor (CLR): Dectin-1 Activation of phagocytosis and cytokine production NM_197948.2 Chr 12:10116777-10130269 2503 570 Xu et al. [38]
10 Phospholipase Cγ2 Promote Dectin-1-mediated Ca2+ flux and cytokine production NM_002661.4 Chr 16:81779258-81962693 8707 3798 Xu et al. [39]
11 Mammalian transient receptor potential protein 2 TRPM2 Aggravates inflammation NM_001320350.1 Chr 21:44350112-44443081 6026 4662 Yamamoto et al. [40]
12 NFATl Involved in the regulation of cytokine gene expression in T lymphocytes NM_001291168.1 Chr 2:168476410-168601657 6644 2724 Savignac et al. [41]
13 NFAT2 Involved in the regulation of cytokine gene expression in T lymphocytes NM_001278669.1 Chr 18:79395772-79529323 5031 2832 Savignac et al. [41]
14 NFAT4 Involved in the regulation of cytokine gene expression in T lymphocytes NM_004555.3 Chr 16:68085366-68229259 6453 3207 Savignac et al. [41]
15 MEF2D Involved in the regulation of cytokine gene expression in T lymphocytes NM_005920.3 Chr 1:156463721-156500842 5996 4186 Savignac et al. [41]
16 DREAM Involved in the regulation of cytokine gene expression in T lymphocytes NM_013434.4 Chr 2:95297324-95386077 2928 771 Savignac et al. [41]
17 IL-8 Activating immunoreaction and proinflammatory NM_001310420.1 Chr Un: 2233607-2236704 1163 312 Tran et al. [42]; Provost et al. [34]
18 TLR (toll-like receptor)-5 Activating immunoreaction NM_016928.3 Chr 1:223108401-223143282 4277 2577 Tran et al. [42]
19 β2 integrins Mediate phagocytosis NM_001303238.1 Chr 21:44885949-44928873 2928 2103 Tran et al. [42]
20 P2Y2 Elicit Ca2+ oscillations activating immunoreaction NM_176072.2 Chr 11:73200416-73246743 8736 1134 Hanley et al. [43]
21 P2X4 ATP induced a transient depolarization activating immunoreaction NM_001256796.1 Chr 12:121209861-121234106 2091 1215 Hanley et al. [43]
22 ll-6 Increased transcription of IL-6 activating immunoreaction NM_000600.4 Chr 7:22725889-22732002 1197 639 Hanley et al. [43]
23 PYK2 Phosphorylation-proinflammatory NM_001183767.3 Chr XV: 984942-986462 1521 1521 Cuschieri et al. [44]
24 p38 Translocation-proinflammatory NM_001078490.1 Chr 11:4821238-4824735 3582 1095 Cuschieri et al. [44]
25 NF-kappaB Translocation-proinflammatory NM_001319226.1 Chr 4:102501329-102617302 3900 2907 Cuschieri et al. [44]
26 AP-1 Nuclear translocation-proinflammatory NM_001334400.1 Chr 1:25982294-25986349 1557 705 Cuschieri et al. [44]
27 TNF-alpha Upregulated-proinflammatory NM_000594.3 Chr 6: 31575567-31578336 1686 702 Cuschieri et al. [44]; Provost et al. [34]
28 ERK 1/2 Phosphorylation-proinflammatory *     Cuschieri et al. [44]
29 29 Fc receptor-lgG Promote receptor-mediated phagocytosis **     Hishikawa et al. [45]
30 Protein kinase C (PKC) Promote nonspecific phagocytosis ***     Hishikawa et al. [45]
  1. * ERK 1/2 are not included as mutiple symbols (references: Cuschieri et al. [44])
  2. ** Fe receptor-lgG are not included as mutiple symbols (references: Hishikawa et al. [45])
  3. *** Protein kinase C (PKC) are not included as mutiple symbols (references: Hishikawa et al. [45])