Table 1 Calcium related gene expression and macrophage functions

1

MIP-1α

Activating inflammatory response

NM_002983.2

Chr 17:36088256-36090160

Provost et al. [34]

2

MIP-1β

Activating inflammatory response

NM_002984.3

Chr 17:36103827-36105621

Provost et al. [34]

3

Toll-like receptor 4 (TLR4)

Activation of TRPC6-dependent calcium signaling mediates endotoxin induced lung vascular permeability and inflammation

NM_021297.3

Chr 9:117704175-117717491

Tauseef et al. [35]

4

STIM1

Mediate extracellular Ca2+ entry

NM_001277961.1

Chr 11:3855703-4093210

Steinckwich et al. [36]

5

Orai1

Mediate extracellular Ca2+ entry

NM_032790.3

Chr 12:121626550-121642040

Steinckwich et al. [36]

6

S100A8

As the site of interplay between extracellular Ca2+ entry and intraphagosomal ROS production

NM_001319197.1

Chr 1:1533590032-153422583

Steinckwich et al. [36]

7

S100A9

As the site of interplay between extracellular Ca2+ entry and intraphagosomal ROS production

NM_002965.3

Chr 1:153357854-153361027

Steinckwich et al. [36]

8

Transient receptor potential vanilloid 2 (TRPV2)

Participation early phagocytosis and innate immunity

NM_016113.4

Chr 17:16415542-16437003

Link et al. [29]

9

lL-10

Activating immunoreaction

NM_000572.2

Chr 1:206767603-206772494

Kelly et al. [37]

C-type lectin receptor (CLR): Dectin-1

Activation of phagocytosis and cytokine production

NM_197948.2

Chr 12:10116777-10130269

Xu et al. [38]

10

Phospholipase Cγ2

Promote Dectin-1-mediated Ca2+ flux and cytokine production

NM_002661.4

Chr 16:81779258-81962693

Xu et al. [39]

11

Mammalian transient receptor potential protein 2 TRPM2

Aggravates inflammation

NM_001320350.1

Chr 21:44350112-44443081

Yamamoto et al. [40]

12

NFATl

Involved in the regulation of cytokine gene expression in T lymphocytes

NM_001291168.1

Chr 2:168476410-168601657

Savignac et al. [41]

13

NFAT2

Involved in the regulation of cytokine gene expression in T lymphocytes

NM_001278669.1

Chr 18:79395772-79529323

Savignac et al. [41]

14

NFAT4

Involved in the regulation of cytokine gene expression in T lymphocytes

NM_004555.3

Chr 16:68085366-68229259

Savignac et al. [41]

15

MEF2D

Involved in the regulation of cytokine gene expression in T lymphocytes

NM_005920.3

Chr 1:156463721-156500842

Savignac et al. [41]

16

DREAM

Involved in the regulation of cytokine gene expression in T lymphocytes

NM_013434.4

Chr 2:95297324-95386077

Savignac et al. [41]

17

IL-8

Activating immunoreaction and proinflammatory

NM_001310420.1

Chr Un: 2233607-2236704

Tran et al. [42]; Provost et al. [34]

18

TLR (toll-like receptor)-5

Activating immunoreaction

NM_016928.3

Chr 1:223108401-223143282

Tran et al. [42]

19

β2 integrins

Mediate phagocytosis

NM_001303238.1

Chr 21:44885949-44928873

Tran et al. [42]

20

P2Y2

Elicit Ca2+ oscillations activating immunoreaction

NM_176072.2

Chr 11:73200416-73246743

Hanley et al. [43]

21

P2X4

ATP induced a transient depolarization activating immunoreaction

NM_001256796.1

Chr 12:121209861-121234106

Hanley et al. [43]

22

ll-6

Increased transcription of IL-6 activating immunoreaction

NM_000600.4

Chr 7:22725889-22732002

Hanley et al. [43]

23

PYK2

Phosphorylation-proinflammatory

NM_001183767.3

Chr XV: 984942-986462

Cuschieri et al. [44]

24

p38

Translocation-proinflammatory

NM_001078490.1

Chr 11:4821238-4824735

Cuschieri et al. [44]

25

NF-kappaB

Translocation-proinflammatory

NM_001319226.1

Chr 4:102501329-102617302

Cuschieri et al. [44]

26

AP-1

Nuclear translocation-proinflammatory

NM_001334400.1

Chr 1:25982294-25986349

Cuschieri et al. [44]

27

TNF-alpha

Upregulated-proinflammatory

NM_000594.3

Chr 6: 31575567-31578336

Cuschieri et al. [44]; Provost et al. [34]

28

ERK 1/2

Phosphorylation-proinflammatory

*

Cuschieri et al. [44]

29

29 Fc receptor-lgG

Promote receptor-mediated phagocytosis

**

Hishikawa et al. [45]

30

Protein kinase C (PKC)

Promote nonspecific phagocytosis

***

Hishikawa et al. [45]