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Fig. 4 | Cell & Bioscience

Fig. 4

From: LncRNA KCNQ1OT1 promotes osteogenic differentiation to relieve osteolysis via Wnt/β-catenin activation

Fig. 4

Effect of RSV on KCNQ1OT1 expression. a ALP activity in mMSCs transfected with sh-KCNQ1OT1 or sh-NC and treated with 40 μM RSV before the addition of PMMA particles. b The mRNA expression levels of Runx2, Osterix and OCN in mMSCs transfected with sh-KCNQ1OT1 or sh-NC and treated with 40 μM RSV before the addition of PMMA particles. c Osteoblastic differentiation in mMSCs transfected with sh-KCNQ1OT1 or sh-NC and treated with 40 μM RSV before the addition of PMMA particles assessed by ARS staining. d The relative expression levels of KCNQ1OT1 in mMSCs transfected with sh-KCNQ1OT1 or sh-NC. *P < 0.05 compared with sh-NC-transfected cells. *P < 0.05 compared with control group. &P < 0.05 compared with PMMA group. #P < 0.05 compared with PMMA + 40 μM RSV + sh-NC group

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