Skip to main content

Advertisement

Table 1 Overview of AQP regulation during inflammation (↑ upregulation, ↓ downregulation, ? unknown regulation, = unaffected)

From: Function of aquaporins in sepsis: a systematic review

Aquaporin Tissue Regulation during inflammation References
AQP1 Immune cells ↑ In leukocytes and cell lines (THP-1) [8, 9]
Heart ↑ In cardiac cells [58]
Lung ↓ In lung tissue after LPS [5, 6]
AQP2 Kidney ↓ In renal tissue after LPS [37]
AQP3 Immune cells ↓ In leukocytes of septic patients [8]
AQP4 Brain ↑ In brain and anterior pituitary gland [31, 75]
AQP5 Lung ↓ In lung tissue after LPS [65]
Immune cells ↓ In THP-1 cells after LPS [9]
AQP7 Immune cells ? Mouse resident peritoneal macrophages [76]
AQP8 Liver ↓ In hepatic cells [11]
Lung = In bronchial epithelial cells [61]
AQP9 Immune cells ↑ In neutrophils of SIRS patients [12]
Immune cells ? Mouse resident peritoneal macrophages [76]
Lung = In bronchial epithelial cells [61]