Skip to main content

Table 1 Overview of AQP regulation during inflammation (↑ upregulation, ↓ downregulation, ? unknown regulation, = unaffected)

From: Function of aquaporins in sepsis: a systematic review

Aquaporin

Tissue

Regulation during inflammation

References

AQP1

Immune cells

↑ In leukocytes and cell lines (THP-1)

[8, 9]

Heart

↑ In cardiac cells

[58]

Lung

↓ In lung tissue after LPS

[5, 6]

AQP2

Kidney

↓ In renal tissue after LPS

[37]

AQP3

Immune cells

↓ In leukocytes of septic patients

[8]

AQP4

Brain

↑ In brain and anterior pituitary gland

[31, 75]

AQP5

Lung

↓ In lung tissue after LPS

[65]

Immune cells

↓ In THP-1 cells after LPS

[9]

AQP7

Immune cells

? Mouse resident peritoneal macrophages

[76]

AQP8

Liver

↓ In hepatic cells

[11]

Lung

= In bronchial epithelial cells

[61]

AQP9

Immune cells

↑ In neutrophils of SIRS patients

[12]

Immune cells

? Mouse resident peritoneal macrophages

[76]

Lung

= In bronchial epithelial cells

[61]