Insights into the roles of lncRNAs in skeletal and dental diseases

Cell & Bioscience

Table 1 Major lncRNAs associated with osteoblastogenesis and osteoclastogenesis, as well as skeletal and dental diseases

lncRNAs	Targets	Effects	References
MouselincRNA0231	Runx2, Osterix	Suppresses osteoblastogenesis	[46]
ANCR	Runx2	Inhibits osteoblastogenesis	[47]
HIF1α-AS1	HOXD10	Promotes osteoblastogenesis	[49]
DANCR	p-GSK-3β, β-catenin	Blocks odontoblast-like differentiation of hDPCs	[50]
DANCR	IL-6, TNF-α	Positively regulates osteoclastogenesis	[55]
MEG3	SLC39A1	Inhibits osteogenic differentiation of BMSCs	[65]
Hotair	PRC2, LSD1 complex	Repressor of skeletal malformation	[67]
SOX9nc2	SOX9	Promotes chondrogenesis	[71]
H19	COL2A1	Stimulates chondrocyte anabolism	[72, 73]
lncRNA-POIR	FoxO1	Positive regulator of osteogenic differentiation in periodontitis	[76]
ANRIL	ADIPOR1, VAMP3, C110RF10	Regulates risk variants of aggressive periodontitis	[77, 78]
TUSC7		Inhibits proliferation in osteosarcoma cells	[81, 82]
MALAT-1	SFPQ, PTBP2	Promotes proliferation, migration, or invasion in osteosarcoma cells	[83,84,85]
LINC340		Potentially involved in ameloblastoma	[89]

ISSN: 2045-3701