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Fig. 6 | Cell & Bioscience

Fig. 6

From: Knockdown of LncRNA MAPT-AS1 inhibites proliferation and migration and sensitizes cancer cells to paclitaxel by regulating MAPT expression in ER-negative breast cancers

Fig. 6

a, b The MDA-MB-231 and MDA-MB-468 cells were pretreated with si-MAPT-AS1, then transfected with MAPT vector or empty vector. The MAPT expression level was determined by qRT-PCR and western blot assays. GAPDH was used as control. cf The two cell lines pretreated with si-MAPT-AS1 were then transfected with MAPT vector or empty vector. The relative cell proliferation was measured using CCK-8 assays and colony-forming assays. And the migration and invasion ability were measured by Transwell assays. g, h The two cell lines pretreated with si-MAPT-AS1 were then transfected with MAPT vector or empty vector, and further exposed to paclitaxel for 24 h before CCK-8 assays or apoptosis detection. The apoptosis rate were measured using flow cytometry assays

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