Fig. 2
From: PML: Regulation and multifaceted function beyond tumor suppression
Overview of PML regulation by multiple stimuli and molecular mechanisms. PML is a stress responsive protein. Upon various extracellular stimuli or DNA damage, as shown in the blue circle, PML is regulated by different mechanisms, from transcription, translation to protein-level regulation, shown in the grey and yellow circle. ISG isgylation, P phosphorylation, Ub ubiquitination, SUMO sumoylation, AC acetylation, cPML cytoplasmic PML, nPML nuclear PML