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Fig. 2 | Cell & Bioscience

Fig. 2

From: PML: Regulation and multifaceted function beyond tumor suppression

Fig. 2

Overview of PML regulation by multiple stimuli and molecular mechanisms. PML is a stress responsive protein. Upon various extracellular stimuli or DNA damage, as shown in the blue circle, PML is regulated by different mechanisms, from transcription, translation to protein-level regulation, shown in the grey and yellow circle. ISG isgylation, P phosphorylation, Ub ubiquitination, SUMO sumoylation, AC acetylation, cPML cytoplasmic PML, nPML nuclear PML

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