Table 7 Altered methylation genes mapped to the neuropathic pain signaling pathway by IPA
From: Epigenetic alterations in TRAMP mice: epigenome DNA methylation profiling using MeDIP-seq
Symbol | Gene name | Log2-fold change | Type(s) |
|---|---|---|---|
GRM3 | Glutamate receptor, metabotropic 3 | − 3.636 | G-protein-coupled receptor |
GRIA1 | Glutamate receptor, ionotropic, AMPA 1 | − 3.167 | Ion channel |
BDNF | Brain-derived neurotrophic factor | − 2.373 | Growth factor |
CREB1 | cAMP-responsive element-binding protein 1 | − 2.274 | Transcription regulator |
GRM7 | Glutamate receptor, metabotropic 7 | − 2.274 | G-protein-coupled receptor |
GRIN3A | Glutamate receptor, ionotropic, N-methyl-D-aspartate 3A | − 2.129 | Ion channel |
MAPK1 | Mitogen-activated protein kinase 1 | 2.048 | Kinase |
TAC1 | Tachykinin, precursor 1 | 2.408 | Other |
CAMK1D | Calcium/calmodulin-dependent protein kinase ID | 2.855 | Kinase |
TACR1 | Tachykinin receptor 1 | 2.855 | G-protein-coupled receptor |
KCNN3 | Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 | 3.119 | Ion channel |
GPR37 | G protein-coupled receptor 37 (endothelin receptor type B-like) | 3.855 | G-protein-coupled receptor |