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Table 6 Top networks analyzed by IPA

From: Epigenetic alterations in TRAMP mice: epigenome DNA methylation profiling using MeDIP-seq

Rank Top diseases and functions Score
1 Tissue morphology, embryonic development, organ development 38
2 Cell-to-cell signaling and interaction, cell signaling, cellular function and maintenance 38
3 Cell death and survival, cancer, cell morphology 37
4 Cancer, gastrointestinal disease, cell death and survival 35
5 Cancer, carbohydrate metabolism, small molecule biochemistry 33
6 Cancer, cell death and survival, cellular response to therapeutics 33
7 Lymphoid tissue structure and development, organ morphology, organismal development 30
8 Cancer, gastrointestinal disease, post-translational modification 29
9 Cancer, dermatological diseases and conditions, gastrointestinal disease 29
10 Cell morphology, digestive system development and function, nervous system development and function 28
11 Cancer, gastrointestinal disease, cell death and survival 26
12 Cancer, drug metabolism, energy production 26
13 Cell-to-cell signaling and interaction, nervous system development and function, cellular development 26
14 Cellular movement, cellular development, skeletal and muscular system development and function 24
15 Cell death and survival, cancer, cellular development 24
16 Hereditary disorder, inflammatory response, metabolic Disease 22
17 Cell morphology, nervous system development and function, tissue morphology 21
18 Cancer, organismal injury and abnormalities, reproductive system disease 21
19 Cellular compromise, cancer, cardiovascular disease 19
20 Cell-to-cell signaling and interaction, tissue development, hematological system development and function 17
21 Cancer, organismal survival, organismal injury and abnormalities 16
22 Cellular assembly and organization, cellular function and maintenance, embryonic development 16
23 Cancer, organismal injury and abnormalities, reproductive system disease 16
24 Cell cycle, cellular movement, cancer 16
25 Cancer, developmental disorder, hereditary disorder 16