Skip to main content

Advertisement

Table 3 Top 50 annotated genes with increased methylation, ranked by log2-fold change

From: Epigenetic alterations in TRAMP mice: epigenome DNA methylation profiling using MeDIP-seq

Rank Symbol Gene name Log2-fold change (TRAMP/WT) Location Type(s) Methylation region
1 FGD4 FYVE, RhoGEF and PH domain containing 4 4.993 Cytoplasm Other Promoter
2 MED13L Mediator complex subunit 13-like 4.993 Nucleus Other Downstream
3 DYNC1I1 Dynein, cytoplasmic 1, intermediate chain 1 4.926 Cytoplasm Other Body
4 XK X-linked Kx blood group 4.781 Plasma membrane Transporter Body
5 EAPP E2F-associated phosphoprotein 4.703 Cytoplasm Other Body
6 TGFA Transforming growth factor, alpha 4.534 Extracellular space Growth factor Promoter
7 BTG1 B-cell translocation gene 1, anti-proliferative 4.440 Nucleus Transcription regulator Promoter
8 BARD1 BRCA1 associated RING domain 1 4.341 Nucleus Transcription regulator Promoter
9 GJA1 Gap junction protein, alpha 1, 43 kDa 4.341 Plasma membrane Transporter Promoter
10 Zfp640 Zinc finger protein 640 4.234 Other Other Downstream
11 S100A5 S100 calcium-binding protein A5 4.119 Nucleus Other Promoter
12 SOX17 SRY (sex-determining region Y)-box 17 4.119 Nucleus Transcription regulator Downstream
13 PDGFRL Platelet-derived growth factor receptor-like 3.993 Plasma membrane Kinase Body
14 ZKSCAN2 Zinc finger with KRAB and SCAN domains 2 3.993 Nucleus Transcription regulator Promoter
15 DMXL2 Dmx-like 2 3.926 Cytoplasm Other Body
16 LEPR Leptin receptor 3.926 Plasma membrane Transmembrane receptor Body
17 AOAH Acyloxyacyl hydrolase (neutrophil) 3.855 Extracellular space Enzyme Promoter
18 Apol7e Apolipoprotein L 7e 3.855 Other Other Body
19 CACNG6 Calcium channel, voltage-dependent, gamma subunit 6 3.855 Plasma membrane Ion channel Promoter
20 CHCHD3 Coiled-coil-helix-coiled-coil-helix domain containing 3 3.855 Cytoplasm Other Body
21 FAM174B Family with sequence similarity 174, member B 3.855 Other Other Body
22 GALNT13 Polypeptide N-acetylgalactosaminyltransferase 13 3.855 Cytoplasm Enzyme Body
23 GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) 3.855 Plasma membrane G-protein coupled receptor Downstream
24 Mup1 Major urinary protein 1 3.855 Extracellular space Other Downstream
25 NGF Nerve growth factor (beta polypeptide) 3.855 Extracellular space Growth factor Downstream
26 OLFM3 Olfactomedin 3 3.855 Cytoplasm Other Body
27 PCBP3 Poly(rC)-binding protein 3 3.855 Nucleus Other Body
28 RBMS3 RNA-binding motif, single-stranded-interacting protein 3 3.855 Other Other Body
29 TMX1 Thioredoxin-related transmembrane protein 1 3.855 Cytoplasm Enzyme Downstream
30 ZNF14 Zinc finger protein 14 3.855 Nucleus Transcription regulator Body
31 SLC1A4 Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 3.807 Plasma membrane Transporter Body
32 ZFAND3 Zinc finger, AN1-type domain 3 3.717 Other Other Body
33 C1orf162 Chromosome 1 open reading frame 162 3.703 Other Transporter Promoter
34 C9orf131 Chromosome 9 open reading frame 131 3.703 Other Other Body
35 CRYZ Crystallin, zeta (quinone reductase) 3.703 Cytoplasm Enzyme Body
36 CYP2A6 Cytochrome P450, family 2, subfamily A, polypeptide 6 3.703 Cytoplasm Enzyme Body
37 CYP51A1 Cytochrome P450, family 51, subfamily A, polypeptide 1 3.703 Cytoplasm Enzyme Downstream
38 DSPP Dentin sialophosphoprotein 3.703 Extracellular space Other Promoter
39 GALNT3 Polypeptide N-acetylgalactosaminyltransferase 3 3.703 Cytoplasm Enzyme Downstream
40 Gm4836 Predicted gene 4836 3.703 Nucleus Other Downstream
41 GRIP1 Glutamate receptor-interacting protein 1 3.703 Plasma membrane Transcription regulator Promoter
42 GUCY1A2 Guanylate cyclase 1, soluble, alpha 2 3.703 Cytoplasm Enzyme Body
43 HNMT Histamine N-methyltransferase 3.703 Cytoplasm Enzyme Body
44 LRRC8B Leucine-rich repeat containing 8 family, member B 3.703 Other Other Body
45 MEF2A Myocyte enhancer factor 2A 3.703 Nucleus Transcription regulator Body
46 NRG3 Neuregulin 3 3.703 Extracellular space Growth factor Promoter
47 PCDH17 Protocadherin 17 3.703 Other Other Promoter
48 PDP2 Pyruvate dehydrogenase phosphatase catalytic subunit 2 3.703 Cytoplasm Phosphatase Promoter
49 SH2D4B SH2 domain containing 4B 3.703 Other Other Body
50 Smok2b Sperm motility kinase 2B 3.703 Other Kinase Body