Table 3 Top 50 annotated genes with increased methylation, ranked by log2-fold change
From: Epigenetic alterations in TRAMP mice: epigenome DNA methylation profiling using MeDIP-seq
Rank | Symbol | Gene name | Log2-fold change (TRAMP/WT) | Location | Type(s) | Methylation region |
|---|---|---|---|---|---|---|
1 | FGD4 | FYVE, RhoGEF and PH domain containing 4 | 4.993 | Cytoplasm | Other | Promoter |
2 | MED13L | Mediator complex subunit 13-like | 4.993 | Nucleus | Other | Downstream |
3 | DYNC1I1 | Dynein, cytoplasmic 1, intermediate chain 1 | 4.926 | Cytoplasm | Other | Body |
4 | XK | X-linked Kx blood group | 4.781 | Plasma membrane | Transporter | Body |
5 | EAPP | E2F-associated phosphoprotein | 4.703 | Cytoplasm | Other | Body |
6 | TGFA | Transforming growth factor, alpha | 4.534 | Extracellular space | Growth factor | Promoter |
7 | BTG1 | B-cell translocation gene 1, anti-proliferative | 4.440 | Nucleus | Transcription regulator | Promoter |
8 | BARD1 | BRCA1 associated RING domain 1 | 4.341 | Nucleus | Transcription regulator | Promoter |
9 | GJA1 | Gap junction protein, alpha 1, 43Â kDa | 4.341 | Plasma membrane | Transporter | Promoter |
10 | Zfp640 | Zinc finger protein 640 | 4.234 | Other | Other | Downstream |
11 | S100A5 | S100 calcium-binding protein A5 | 4.119 | Nucleus | Other | Promoter |
12 | SOX17 | SRY (sex-determining region Y)-box 17 | 4.119 | Nucleus | Transcription regulator | Downstream |
13 | PDGFRL | Platelet-derived growth factor receptor-like | 3.993 | Plasma membrane | Kinase | Body |
14 | ZKSCAN2 | Zinc finger with KRAB and SCAN domains 2 | 3.993 | Nucleus | Transcription regulator | Promoter |
15 | DMXL2 | Dmx-like 2 | 3.926 | Cytoplasm | Other | Body |
16 | LEPR | Leptin receptor | 3.926 | Plasma membrane | Transmembrane receptor | Body |
17 | AOAH | Acyloxyacyl hydrolase (neutrophil) | 3.855 | Extracellular space | Enzyme | Promoter |
18 | Apol7e | Apolipoprotein L 7e | 3.855 | Other | Other | Body |
19 | CACNG6 | Calcium channel, voltage-dependent, gamma subunit 6 | 3.855 | Plasma membrane | Ion channel | Promoter |
20 | CHCHD3 | Coiled-coil-helix-coiled-coil-helix domain containing 3 | 3.855 | Cytoplasm | Other | Body |
21 | FAM174B | Family with sequence similarity 174, member B | 3.855 | Other | Other | Body |
22 | GALNT13 | Polypeptide N-acetylgalactosaminyltransferase 13 | 3.855 | Cytoplasm | Enzyme | Body |
23 | GPR37 | G protein-coupled receptor 37 (endothelin receptor type B-like) | 3.855 | Plasma membrane | G-protein coupled receptor | Downstream |
24 | Mup1 | Major urinary protein 1 | 3.855 | Extracellular space | Other | Downstream |
25 | NGF | Nerve growth factor (beta polypeptide) | 3.855 | Extracellular space | Growth factor | Downstream |
26 | OLFM3 | Olfactomedin 3 | 3.855 | Cytoplasm | Other | Body |
27 | PCBP3 | Poly(rC)-binding protein 3 | 3.855 | Nucleus | Other | Body |
28 | RBMS3 | RNA-binding motif, single-stranded-interacting protein 3 | 3.855 | Other | Other | Body |
29 | TMX1 | Thioredoxin-related transmembrane protein 1 | 3.855 | Cytoplasm | Enzyme | Downstream |
30 | ZNF14 | Zinc finger protein 14 | 3.855 | Nucleus | Transcription regulator | Body |
31 | SLC1A4 | Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 3.807 | Plasma membrane | Transporter | Body |
32 | ZFAND3 | Zinc finger, AN1-type domain 3 | 3.717 | Other | Other | Body |
33 | C1orf162 | Chromosome 1 open reading frame 162 | 3.703 | Other | Transporter | Promoter |
34 | C9orf131 | Chromosome 9 open reading frame 131 | 3.703 | Other | Other | Body |
35 | CRYZ | Crystallin, zeta (quinone reductase) | 3.703 | Cytoplasm | Enzyme | Body |
36 | CYP2A6 | Cytochrome P450, family 2, subfamily A, polypeptide 6 | 3.703 | Cytoplasm | Enzyme | Body |
37 | CYP51A1 | Cytochrome P450, family 51, subfamily A, polypeptide 1 | 3.703 | Cytoplasm | Enzyme | Downstream |
38 | DSPP | Dentin sialophosphoprotein | 3.703 | Extracellular space | Other | Promoter |
39 | GALNT3 | Polypeptide N-acetylgalactosaminyltransferase 3 | 3.703 | Cytoplasm | Enzyme | Downstream |
40 | Gm4836 | Predicted gene 4836 | 3.703 | Nucleus | Other | Downstream |
41 | GRIP1 | Glutamate receptor-interacting protein 1 | 3.703 | Plasma membrane | Transcription regulator | Promoter |
42 | GUCY1A2 | Guanylate cyclase 1, soluble, alpha 2 | 3.703 | Cytoplasm | Enzyme | Body |
43 | HNMT | Histamine N-methyltransferase | 3.703 | Cytoplasm | Enzyme | Body |
44 | LRRC8B | Leucine-rich repeat containing 8 family, member B | 3.703 | Other | Other | Body |
45 | MEF2A | Myocyte enhancer factor 2A | 3.703 | Nucleus | Transcription regulator | Body |
46 | NRG3 | Neuregulin 3 | 3.703 | Extracellular space | Growth factor | Promoter |
47 | PCDH17 | Protocadherin 17 | 3.703 | Other | Other | Promoter |
48 | PDP2 | Pyruvate dehydrogenase phosphatase catalytic subunit 2 | 3.703 | Cytoplasm | Phosphatase | Promoter |
49 | SH2D4B | SH2 domain containing 4B | 3.703 | Other | Other | Body |
50 | Smok2b | Sperm motility kinase 2B | 3.703 | Other | Kinase | Body |