Skip to main content

Advertisement

Fig. 3 | Cell & Bioscience

Fig. 3

From: Heart regeneration in adult Xenopus tropicalis after apical resection

Fig. 3

Adult X. tropicalis heart has capacity for regeneration after resection. a1 Longitudinal section of an adult heart from the non-amputated sham control. Bar = 400 μm. a2 High magnification of the region outlined by rectangle in a1. Bar = 100 μm. a3 High magnification of the rectangle region in a2. Bar = 20 μm. b1b3 An amputated heart at 0 daar (approximately 30 min after amputation), showing activated inflammation and hyperemia at the border of the injury. c1c3 An amputated heart at 1 daar, showing a membrane-like structure (arrow) close to the outer surface of the scar tissue which exhibited with inflammatory cell infiltration, and red blood cells accumulation below the membrane-like structure. c2′ High power of the membrane-like structure which is consisted of cellular or some extracellular matrix. d1d3 An amputated heart at 2 daar, showing more inflammatory cells in the regenerated area compared with 1 daar. e1e3 An amputated heart at 4 daar, showing an increase of inflammatory cells and a decrease of red blood cells in the regenerated area compared with 2 daar. f1f3 An amputated heart at 8 daar, showing the disappearance of most infiltrated red blood cells and a significant decrease of the inflammatory cell intensity in the regenerated area. g1g3 Most of the fibrous tissue production was replaced with newly regenerated cardiomyocytes and some of the newly regenerated cardiac myocytes are matured, as indicated by a more regular cardiac-specific cross-striated morphology at 16 daar (g3′). h1h3, i1i3 An amputated heart regenerated with a perfect morphology and nearly perfect morphology at 30 daar. The amputated area was regenerated with mature cardiomyocytes. In addition, the regenerated myocardium has an intact epicardium (arrow). j1–j3, k1k3 An amputated heart regenerated with a perfect morphology and nearly perfect morphology at 60 daar. The amputated area was regenerated with mature cardiomyocytes. An intact epicardial structure (arrow) in the regenerated myocardium. R regenerated area, B border area. White star: showing red blood cells; White arrows: showing inflammation cells. Six frogs were inspected for 30 and 60 daar, while three frogs were inspected for other time points respectively

Back to article page