Table 1 Mass spectrometry analysis results of chosen proteins
Protein name | Gene name | Full name | qvalue | Ratio | Fold change | Peptide no. | Citation (protein association with RCC or cancerogenesis or hypoxia) | Function (main process) |
|---|---|---|---|---|---|---|---|---|
P23588 | eif4b | Eukaryotic translation initiation factor B | NA | SH/AN: only rSH N: 0 rAN: 0 H: 0 rSH: 1 | NA | 2 | [57] | Signal transduction |
Q02750 | map2k1 | Dual specificity mitogen-activated protein kinase 1 | NA | N/H: only H N: 0 H: 1 rSH: 0 rAN: 0 | NA | 5 | Signal transduction | |
Q99459 | cdc5Â l | Cell division cycle 5-like protein | NA | Only rSH (rSH/rAN) | NA | 2 | [60] | Cell cycling |
O60264 | smarca5 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 | NA | Only rSH (rSH/rAN) | NA | 3 | [61] | Nucleosome-remodeling activity |
Q9UIG0 | baz1b | Tyrosine-protein kinase BAZ1B | NA | Only rAN (AN/N) | NNA | 2 | [62] | Chromatin remodeling |
P07910 | hnrnp | Heterogene-ous nuclear ribonucleo-proteins C1/C2 | NA | Only rAN (rAN/N) | NNA | 2 | [63] | Regulation of mRNA splicing |
P14618 | pkm | Pyruvate kinase PKM | 0.00013 (H/N) 0.00011 (rSH/rAN) | 2.34 (H/N) 1.89 (rSH/rAN) | 2.34 (H/N) 1.89 (rSH/rAN) | 45 (H/N) 42 (rSH/rAN) | [64] | Metabolic (production of ATP) |
P05091 | aldh2 | Aldehyde dehydroge-nase, mitochon-drial | NA | Only H (H/N) Only rAN (rAN/N) | NA | 4 (H/N) 3 (rAN/N) | [65] | Alcohol metabolism, marker for stem cells |
Q9BXP5 | srrt | Serrate RNA effector molecule homolog | NA | Only H (SH/H) | NA | 2 | [66] | Cell proliferation |
P62258 | 14-3-3ε | 14-3-3 epsilon | 0.00027 | 1,7 (rSH/rAN) | 1,7 (rSH/rAN) | 21 | [67] | Is believed to play a role in G2/M transition |
Q9NYF8 | bclaf1 | Bcl-2-associated transcription factor 1 | NA | Only rSH (rSH/H) | NA | 2 | [68] | Apoptosis, negative regulation of transciption |
P00338 | ldha | L-lactate dehydrogenase A chain | 0.00011 (SH/AN) 0.00816 (H/N) | 2.54 (rSH/rAN) 1.91 (H/N) | 2.52 (rSH/rAN) 1.91 (H/N) | 17 (rSH/rAN) 16 (H/N) | [69] | Metabolic—higher levels in cancer |