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Fig. 5 | Cell & Bioscience

Fig. 5

From: Hypoxic 3D in vitro culture models reveal distinct resistance processes to TKIs in renal cancer cells

Fig. 5

Heterogenous aggregate formation in suspension culture of HKCSCs before protein isolation for mass spectrometry and Western blotting at day 6 of the culture prove resistance of HKCSCs to sorafenib in hypoxia and axitinib in normoxia. Reduced proliferation rates in lower oxygen tension is shown. Resistant HKCSCs are marked with a black square. Magnification: 4×, scale bar = 200 µm

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