Fig. 6
From: The lncRNA MEG3 downregulation leads to osteoarthritis progression via miR-16/SMAD7 axis
MEG3 exerted its effect on anti-proliferation and pro-apoptosis by regulating SMAD7. IL-1β-induced chondrocytes were transfected with si-NC, si-MEG3, si-MEG3 + pcDNA-NC, si-MEG3 + pcDNA-SMAD7, pcDNA-NC, pcDNA-MEG3, pcDNA-MEG3 + si-NC or pcDNA-MEG3 + si-SMAD7. a Cell viability of treated IL-1β-induced chondrocytes was determined. b Flow cytometry of cell apoptosis in treated IL-1β-induced chondrocytes. c Bax and Bcl2 expression were detected in treated IL-1β-induced chondrocytes. *P < 0.05 vs. negative control