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Fig. 3 | Cell & Bioscience

Fig. 3

From: 14-3-3ζ loss leads to neonatal lethality by microRNA-126 downregulation-mediated developmental defects in lung vasculature

Fig. 3

miR-126 regulates angiogenesis downstream of 14-3-3ζ. a qRT-PCR analysis of miR-126 expression normalized to PECAM1 in the lungs from 14-3-3ζ wild type (+/+) and knockout (−/−) embryo lungs, ± SD (n = 3) *p < 0.05. b qRT-PCR analysis of miR-126 expression normalized to PECAM1 in the lungs from 14-3-3ζ wild type (+/+) mice (6 weeks) from the indicated genetic backgrounds. c Detection of 14-3-3ζ and β-actin by western blotting in mouse endothelial cells expressing either a scrambled shRNA or shRNA targeting 14-3-3ζ. d qRT-PCR analysis of miR-126 expression normalized to PECAM1 in mouse endothelial cells expressing either a scrambled shRNA or shRNA targeting 14-3-3ζ. ± SD (n = 3)

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