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Fig. 2 | Cell & Bioscience

Fig. 2

From: 14-3-3ζ loss leads to neonatal lethality by microRNA-126 downregulation-mediated developmental defects in lung vasculature

Fig. 2

14-3-3ζ mediated neonatal lethality and associated defects in lung development. a 18.5 dpc embryos were dissected using caesarean section. Representative photos of 14-3-3ζ wild type (+/+) and homozygous mutant (−/−) are shown as indicated. b Lung tissues from the embryos were immersed in water to determine buoyancy. c Hematoxylin and eosin staining of the lungs dissected from the embryos. Sample size is indicated. d IHC staining for Ki-67 on the lungs dissected from +/+ and −/− embryos. e IHC staining for SP-A on the lungs dissected from +/+ and −/− embryos. f IHC staining for AQP5 on the lungs dissected from +/+ and −/− embryos. g IHC staining for CD34 on the lungs dissected from +/+ and −/− embryos. Length of the scale bar represents 50 µm in each panel. dg Right: the quantification of the IHC stainings by immunoreactive score (IRS). ***, **, * Indicate p < 0.001, 0.01, and 0.05, respectively. n.s.: not significant

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