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Fig. 5 | Cell & Bioscience

Fig. 5

From: Sirtinol regulates the balance of Th17/Treg to prevent allograft rejection

Fig. 5

Sirtinol synergizes with FK506 to prevent mouse cardiac allograft rejection. a Fully MHC-mismatched cardiac allograft recipients (BALB/C to C57BL/6) were treated with DMSO, sirtinol (1 mg/kg/day), FK506 (1 mg/kg/day) or sirtinol (1 mg/kg/day)—FK506 (1 mg/kg/day) combination by intraperitoneal injection since the day after transplantation until when cardiac arrest occurred. Graft survival was assessed every day. b Pathological examination of allografts harvested on day 12 post-transplantation. Shown are section graphs from the low power field and high power field. c Infiltrating cells per high power field were counted from five mice per group. d, e IL-17A and Foxp3 mRNA were measured by qPCR. The data are expressed as mean ± SD (n = 5). *P < 0.05, **P < 0.01. NC negative control represented cardiac graft from isotransplantation

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