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Fig. 4 | Cell & Bioscience

Fig. 4

From: Sirtinol regulates the balance of Th17/Treg to prevent allograft rejection

Fig. 4

Sirtinol regulates Th17/Treg balance. a Naive CD4+ T cells were isolated from mouse spleen, and polarized for Th17 differentiation in the presence different concentration of sirtinol. IL-17A expressing CD4+ T cells were measured by flow cytometry. Shown are representative of five separate experiments. b Percentages of IL-17A+ cells were presented. c The effect of sirtinol on the expressions of RORγt and Foxp3 measured by western blots. Shown are representative of five separate experiments. df Gene expressions of IL-17A, RORγt, Foxp3 in CD4+ T cells measured by qPCR. The data are expressed as mean ± SD (n = 5). *P < 0.05, **P < 0.01, compared with DMSO group

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