Fig. 3

Immunostaining of GSTpi shows relative abundence of mature oligodendrocytes in CD1 mice relative to C57BL/6 mice after various length of cuprizone exposure. a Representative images of GSTpi+ mature oligodendrocytes at the midline of the corpus callosum. Scale bar, 30 μm. b Quantification of cell density counts. Note CD1 mice and C57BL/6 mice show comparable numbers of mature oligodendrocytes under control conditions. Asterisks above brackets indicate significant differences between strains were observed at all time points of treatment (two way ANOVA analysis for interaction between strain and cuprizone treatment. *P < 0.05; **P < 0.01). Asterisks above the bars indicate significant difference from respective controls (t-test, *P < 0.05; **P < 0.01). Error bars show SEM. N numbers are indicated on individual bars