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Fig. 4 | Cell & Bioscience

Fig. 4

From: Phosphorylation of astrocytic connexin43 by ERK1/2 impairs blood–brain barrier in acute cerebral ischemia

Fig. 4

In vivo administration of ERK inhibitor SCH772984 or siRNA prevents ischemia-induced brain infarction. a Different dosage of SCH772984 treatment (1, 5, 10 µg/g brain) attenuate brain edema at 8 h after bilateral common carotid artery occlusion. b In vivo transfection of ERK1/2 siRNA attenuates brain edema at 8 h after bilateral common carotid artery occlusion. c Western blotting results of the ERK1/2 protein level reduction at 48 h after siRNA transfection. Data is presented as mean ± SEM. *p < 0.05, **p < 0.01 and ***p < 0.001

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