Fig. 3

ERK1/2 signaling regulates phosphorylation of Cx43. a Sample image and b statistical analysis of Cx43 phosphorylation in astrocytes after application of 16 kinase inhibitors. c, d ERK inhibitor SCH772984 and siRNA effectively reduced Cx43 phosphorylation level without affecting Cx40 and Cx43 total protein levels in cultured astrocytes. Data is presented as mean ± SEM. *p < 0.05, **p < 0.01 and ***p < 0.001