Fig. 5From: The miR-290-295 cluster as multi-faceted players in mouse embryonic stem cellsThe Hox genes are associated with ESC differentiation, but they are maintained inactive in ESCs due to the action of PcG proteins. Ash1l activates Hox genes through evicting Polycomb during differentiation. miR-290-295 cluster members downregulate the expression of Ash1l to maintain pluripotencyBack to article page