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Fig. 3 | Cell & Bioscience

Fig. 3

From: Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight

Fig. 3

a The IDH1 dimer type formed in a cancer cell that is homozygous for IDH1 R132 mutation. IDH1 isocitrate dehydrogenase isoform 1, Mut mutant (e.g. IDH1 R132). b The model explains the absence of IDH1 R132 homozygosity in cancer cells. Since only the Mut-Mut homodimer will be produced in the cancer cell that is homozygous for IDH1 R132, no (D)-2HG will be produced and therefore the oncometabolite drive will be lost causing that particular cancer cell to regress and undergo apoptosis. ICT isocitrate, Mut mutant (e.g. IDH1 R132), Wt wild type, 2KG 2-keto glutarate. The dotted red line indicates inhibition. The crossed black lines indicate loss of enzyme function in both directions

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