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Fig. 2 | Cell & Bioscience

Fig. 2

From: Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight

Fig. 2

a The three dimer types formed in a cancer cell heterozygous for IDH1 mutation. Mut mutant, Wt wild type. b The model gain of function and dominant negative effect exerted by heterozygous IDH1/2 mutation. (D)-2HG (d) 2-hydroxy glutarate, ICT isocitrate, Mut mutant, Wt wild type, 2KG 2-keto glutarate. The dotted red line indicates inhibition. The crossed black lines indicate loss of enzyme function in both directions

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