Fig. 2From: Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight a The three dimer types formed in a cancer cell heterozygous for IDH1 mutation. Mut mutant, Wt wild type. b The model gain of function and dominant negative effect exerted by heterozygous IDH1/2 mutation. (D)-2HG (d) 2-hydroxy glutarate, ICT isocitrate, Mut mutant, Wt wild type, 2KG 2-keto glutarate. The dotted red line indicates inhibition. The crossed black lines indicate loss of enzyme function in both directionsBack to article page