Fig. 8

The miR-199 family and miR-200 family members regulate hepatic fibrosis by following ways: (1) miR-199a reduces the level of CAV-1 and then promotes the phosphorylation of Smad2; (2) miR-200a downregulates Keap1 and activates the transcription of many cytoprotective genes which involve in the elimination of ROS; (3) miR-200a inhibits TGF-β/Smad pathway by targeting TGF-β2; (4) miR-200c targets FAP1 and then activates cSrc resulting in promoting TGF-β/Smad pathway